diff --git a/src/Umbraco.Web.UI.Client/src/packages/content/content/workspace/content-detail-workspace-base.ts b/src/Umbraco.Web.UI.Client/src/packages/content/content/workspace/content-detail-workspace-base.ts
index 1f2fa3151d..1420b1e56e 100644
--- a/src/Umbraco.Web.UI.Client/src/packages/content/content/workspace/content-detail-workspace-base.ts
+++ b/src/Umbraco.Web.UI.Client/src/packages/content/content/workspace/content-detail-workspace-base.ts
@@ -714,6 +714,10 @@ export abstract class UmbContentDetailWorkspaceContextBase<
 	 */
 	public async runMandatoryValidationForSaveData(saveData: DetailModelType, variantIds: Array<UmbVariantId> = []) {
 		// Check that the data is valid before we save it.
+		// If we vary by culture then we do not want to validate the invariant variant.
+		if (this.getVariesByCulture()) {
+			variantIds = variantIds.filter((variant) => !variant.isCultureInvariant());
+		}
 		const missingVariants = variantIds.filter((variant) => {
 			return !saveData.variants.some((y) => variant.compare(y));
 		});